A novel pathway for lipid biosynthesis: the direct acylation of glycerol

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A novel pathway for lipid biosynthesis: the direct acylation of glycerol.

The acylation of glycerol-3-phosphate by acyl-CoA is regarded as the first committed step for the synthesis of the lipoidal moiety in glycerolipids. The direct acylation of glycerol in mammalian tissues has not been demonstrated. In this study, lipid biosynthesis in myoblasts and hepatocytes was reassessed by conducting pulse-chase experiments with [1,3-(3)H]glycerol. The results demonstrated t...

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ژورنال

عنوان ژورنال: Journal of Lipid Research

سال: 2001

ISSN: 0022-2275

DOI: 10.1016/s0022-2275(20)31526-1